Ontology highlight
ABSTRACT:
SUBMITTER: Litterman NK
PROVIDER: S-EPMC4955571 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Journal of chemical information and modeling 20141007 10
In a decade with over half a billion dollars of investment, more than 300 chemical probes have been identified to have biological activity through NIH funded screening efforts. We have collected the evaluations of an experienced medicinal chemist on the likely chemistry quality of these probes based on a number of criteria including literature related to the probe and potential chemical reactivity. Over 20% of these probes were found to be undesirable. Analysis of the molecular properties of the ...[more]