Ontology highlight
ABSTRACT:
SUBMITTER: Foust BJ
PROVIDER: S-EPMC4955788 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Foust Benjamin J BJ Allen Cheryl C Holstein Sarah A SA Wiemer David F DF
Bioorganic & medicinal chemistry 20160610 16
The enzyme geranylgeranyl diphosphate synthase (GGDPS) is believed to receive the substrate farnesyl diphosphate through one lipophilic channel and release the product geranylgeranyl diphosphate through another. Bisphosphonates with two isoprenoid chains positioned on the α-carbon have proven to be effective inhibitors of this enzyme. Now a new motif has been prepared with one isoprenoid chain on the α-carbon, a second included as a phosphonate ester, and the potential for a third at the α-carbo ...[more]