Kruppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1.
Ontology highlight
ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC4956169 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1.
Kim Sun-Hee SH Park Yun-Yong YY Cho Sung-Nam SN Margalit Ofer O Wang Dingzhi D DuBois Raymond N RN
PloS one 20160721 7
Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. T ...[more]
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