Ontology highlight
ABSTRACT:
SUBMITTER: Gal A
PROVIDER: S-EPMC4956300 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Gal Arnon A Lin Po-Ching PC Cacioppo Joseph A JA Hannon Patrick R PR Mahoney Megan M MM Wolfe Andrew A Fernandez-Valdivia Rodrigo R Lydon John P JP Elias Carol F CF Ko CheMyong C
PloS one 20160721 7
Ovarian steroids, estradiol and progesterone, play central roles in regulating female reproduction by acting as both positive and negative regulators of gonadotropin-releasing hormone (GnRH) secretion in the hypothalamus. Recent studies have identified kisspeptin neurons of the hypothalamus as the target of estrogenic regulation of GnRH secretion. In this study, we aimed to determine the significance of progesterone receptor (PGR) expression in the kisspeptin neurons. To this end, the Pgr gene w ...[more]