Ontology highlight
ABSTRACT:
SUBMITTER: Karimova M
PROVIDER: S-EPMC4957104 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Karimova Madina M Splith Victoria V Karpinski Janet J Pisabarro M Teresa MT Buchholz Frank F
Scientific reports 20160722
Precise genome engineering is instrumental for biomedical research and holds great promise for future therapeutic applications. Site-specific recombinases (SSRs) are valuable tools for genome engineering due to their exceptional ability to mediate precise excision, integration and inversion of genomic DNA in living systems. The ever-increasing complexity of genome manipulations and the desire to understand the DNA-binding specificity of these enzymes are driving efforts to identify novel SSR sys ...[more]