A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation.
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ABSTRACT:
SUBMITTER: Duran CG
PROVIDER: S-EPMC4957339 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation.
Duran Charity G CG Burbank Allison J AJ Mills Katherine H KH Duckworth Heather R HR Aleman Maria M MM Kesic Matthew J MJ Peden David B DB Pan Yinghao Y Zhou Haibo H Hernandez Michelle L ML
Respiratory research 20160722 1
<h4>Unlabelled</h4>Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure mod ...[more]
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