Ontology highlight
ABSTRACT:
SUBMITTER: Wynn JE
PROVIDER: S-EPMC4957400 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Wynn Jessica E JE Zhang Wenyu W Tebit Denis M DM Gray Laurie R LR Hammarskjold Marie-Louise ML Rekosh David D Santos Webster L WL
MedChemComm 20160606 7
High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids <b>A5</b>, <b>A6</b>, and <b>A7</b> inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner. ...[more]