Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Perri JI
PROVIDER: S-EPMC4957981 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Perez-Perri Joel I JI Dengler Veronica L VL Audetat K Audrey KA Pandey Ahwan A Bonner Elizabeth A EA Urh Marjeta M Mendez Jacqui J Daniels Danette L DL Wappner Pablo P Galbraith Matthew D MD Espinosa Joaquín M JM
Cell reports 20160616 1
Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as a HIF1 transcriptional cofactor in Drosophila and human cells. TIP60 (KAT5) is required for HIF1-dependent gene expression in fly cells and embryos and colorectal cancer cells. HIF1 ...[more]