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Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.

ABSTRACT: The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

SUBMITTER: Yu H 

PROVIDER: S-EPMC4958199 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.

Yu Hua H   Qu Fen F   Shan Bin B   Huang Bin B   Jia Wei W   Chen Cha C   Li Aiqing A   Miao Minhui M   Zhang Xin X   Bao Chunmei C   Xu Yunmin Y   Chavda Kalyan D KD   Tang Yi-Wei YW   Kreiswirth Barry N BN   Du Hong H   Chen Liang L  

Antimicrobial agents and chemotherapy 20160722 8

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first descr  ...[more]

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