Ontology highlight
ABSTRACT:
SUBMITTER: Kar SS
PROVIDER: S-EPMC4958353 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kar Sidhartha S SS Bhat G Varadaraj V Rao Praveen Pn PP Shenoy Vishnu P VP Bairy Indira I Shenoy G Gautham GG
Drug design, development and therapy 20160718
A series of triclosan mimic diphenyl ether derivatives have been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The binding mode of the compounds at the active site of enoyl-acyl carrier protein reductase of M. tuberculosis has been explored. Among them, compound 10b was found to possess antitubercular activity (minimum inhibitory concentration =12.5 µg/mL) comparable to triclosan. All the synthesized compounds exhibited low levels ...[more]