Ontology highlight
ABSTRACT:
SUBMITTER: Henrique D
PROVIDER: S-EPMC4958456 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Henrique Domingos D Abranches Elsa E Verrier Laure L Storey Kate G KG
Development (Cambridge, England) 20150901 17
Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However, as the molecular mechanisms that specify NMps in vivo are uncovered, and as protocols for generating these bipotent cells from mouse and human pluripotent stem cells in vitro are established, the emerging data suggest that this view needs to be revised. Here, we review the c ...[more]