Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee Mustafi S
PROVIDER: S-EPMC4958591 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Banerjee Mustafi Soumyajit S Chakraborty Prabir Kumar PK Naz Sarwat S Dwivedi Shailendra Kumar Dhar SK Street Mark M Basak Rumki R Yang Da D Ding Kai K Mukherjee Priyabrata P Bhattacharya Resham R
Biochimica et biophysica acta 20160622 8
Chemotherapy-induced emergence of drug resistant cells is frequently observed and is exemplified by the expression of family of drug resistance proteins including, multidrug resistance protein 1 (MDR1). However, a concise mechanism for chemotherapy-induced MDR1 expression is unclear. Mechanistically, mutational selection, epigenetic alteration, activation of the Wnt pathway or impaired p53 function have been implicated. The present study describes that the surviving fraction of cisplatin resista ...[more]