Immune DNA signature of T-cell infiltration in breast tumor exomes.
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ABSTRACT:
SUBMITTER: Levy E
PROVIDER: S-EPMC4958917 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Immune DNA signature of T-cell infiltration in breast tumor exomes.
Levy Eric E Marty Rachel R Gárate Calderón Valentina V Woo Brian B Dow Michelle M Armisen Ricardo R Carter Hannah H Harismendy Olivier O
Scientific reports 20160725
Tumor infiltrating lymphocytes (TILs) have been associated with favorable prognosis in multiple tumor types. The Cancer Genome Atlas (TCGA) represents the largest collection of cancer molecular data, but lacks detailed information about the immune environment. Here, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-cell receptor beta (TCRB) can be used as an immune DNA (iDNA) signature. Specifically, we propose a method to identify CDR3 reads in a br ...[more]
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