The Association of FTO SNP rs9939609 with Weight Gain at University.

ABSTRACT:

Aim

We tested the hypothesis that the obesity-associated FTO SNP rs9939609 would be associated with clinically significant weight gain (≥ 5% of initial body weight) in the first year of university; a time identified as high risk for weight gain.

Methods

We collected anthropometric data from university students (n = 1,411, mean age: 22.4 ± 2.5 years, 49.1% male) at the beginning and end of the academic year. DNA was analysed for FTO rs9939609. Associations of FTO genotype with BMI at baseline were analysed using ANCOVA, and with risk of 5% weight gain over follow-up with logistic regression; both analyses adjusting for age and sex. The alpha level was reduced to 0.0125 to account for multiple testing.

Results

Using an additive model, FTO status was not associated with

SUBMITTER: Meisel SF 

PROVIDER: S-EPMC4959463 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature