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Remote Control of T Cell Activation Using Magnetic Janus Particles.


ABSTRACT: We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle-cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single-cell activities without the need of complex magnetic manipulation devices.

SUBMITTER: Lee K 

PROVIDER: S-EPMC4959603 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Remote Control of T Cell Activation Using Magnetic Janus Particles.

Lee Kwahun K   Yi Yi Y   Yu Yan Y  

Angewandte Chemie (International ed. in English) 20160504 26


We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle-cell recognition and thereby the initiation of T cell activation. This study  ...[more]

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