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Ibrutinib in Waldenstrom macroglobulinemia: latest evidence and clinical experience.


ABSTRACT: Ibrutinib is an oral Bruton's tyrosine kinase (BTK) inhibitor, which has recently gained approval by the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of patients with symptomatic Waldenström macroglobulinemia (WM). Herein, we review the role of BTK in the pathophysiology of WM, and present the results of the preclinical and clinical studies that led to the initial investigation and later approval of ibrutinib in WM. We also discuss aspects associated with ibrutinib therapy in WM patients, especially focusing on genomic profiling and the impact on response to ibrutinib, and the management of adverse events.

SUBMITTER: Castillo JJ 

PROVIDER: S-EPMC4959643 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Ibrutinib in Waldenström macroglobulinemia: latest evidence and clinical experience.

Castillo Jorge J JJ   Palomba M Lia ML   Advani Ranjana R   Treon Steven P SP  

Therapeutic advances in hematology 20160613 4


Ibrutinib is an oral Bruton's tyrosine kinase (BTK) inhibitor, which has recently gained approval by the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of patients with symptomatic Waldenström macroglobulinemia (WM). Herein, we review the role of BTK in the pathophysiology of WM, and present the results of the preclinical and clinical studies that led to the initial investigation and later approval of ibrutinib in WM. We also discu  ...[more]

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