Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4960006 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Li Yajuan Y Lauriola Mattia M Kim Donghwa D Francesconi Mirko M D'Uva Gabriele G Shibata Dave D Malafa Mokenge P MP Yeatman Timothy J TJ Coppola Domenico D Solmi Rossella R Cheng Jin Q JQ
Oncogene 20160125 35
Adenomatous polyposis coli (APC) mutation is the most common genetic change in sporadic colorectal cancer (CRC). Although deregulations of miRNAs have been frequently reported in this malignancy, APC-regulated miRNAs have not been extensively documented. Here, by using an APC-inducible cell line and array analysis, we identified a total of 26 deregulated miRNAs. Among them, members of miR-17-92 cluster were dramatically inhibited by APC and induced by enforced expression of β-catenin. Furthermor ...[more]