Ontology highlight
ABSTRACT:
SUBMITTER: Mishra RK
PROVIDER: S-EPMC4960487 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Mishra Rama K RK Shum Andrew K AK Platanias Leonidas C LC Miller Richard J RJ Schiltz Gary E GE
Scientific reports 20160726
The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 are involved in a large number of physiological processes including HIV-1 infectivity, inflammation, tumorigenesis, stem cell migration, and autoimmune diseases. While previous efforts have identified a number of CXCR4 antagonists, there have been no small molecule agonists reported. Herein, we describe the identification of a novel series of CXCR4 modulators, including the first small molecules to display agonist behavior against this ...[more]