Ontology highlight
ABSTRACT:
SUBMITTER: Zhao T
PROVIDER: S-EPMC4960563 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Zhao Tingting T Xu Zhi Z Gu Dongying D Wu Peng P Huo Xinying X Wei Xiaowei X Tang Yongfei Y Gong Weida W He Ming-Liang ML He Ming-Liang ML Chen Jinfei J
Scientific reports 20160726
5-fluorouracil (5-FU) is widely used to treat patients with gastric cancer (GC). However, the response rate is quite heterogeneous. The single nucleotide polymorphisms (SNPs) and their interactions of genes in the one-carbon metabolism (OCM) pathway, including Methylenetetrahydrofolate reductase (MTHFR), Methionine synthase reductase (MTRR), Methionine synthase (MTR), and Thymidylate synthase (TS), significantly affect 5-FU metabolism. In this study, 650 stage II-III patients were recruited from ...[more]