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DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs.

ABSTRACT: The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim.

SUBMITTER: Cheng L

PROVIDER: S-EPMC4960572 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs.

Cheng Liang L Jiang Yue Y Wang Zhenzhen Z Shi Hongbo H Sun Jie J Yang Haixiu H Zhang Shuo S Hu Yang Y Zhou Meng M

Scientific reports 20160726

The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, Dis ...[more]

PMID: 27457921

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DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs.

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DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs.

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