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Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats.


ABSTRACT: Renal aging is always accompanied by increased oxidative stress. Hydrogen sulfide (H2S) can be up-regulated by 50% dietary restriction (DR) for 7-day and can block mitochondrial oxidative stress. H2S production exerts a critical role in yeast, worm, and fruit fly models of DR-mediated longevity. In this study, we found that renal aging could be attenuated by 30% DR for 6-month (DR-6M) and life-long (DR-LL), but not for 6-week (DR-6W). The expressions of cystathionine-?-lyase (CGL) and cystathionine-?- synthase (CBS) were improved by DR-6M and DR-LL. Endogenous H2S production shared the same trend with CBS and CGL, while glutathione (GSH) didn't. When comparing efficiencies of DR for different durations, more evident production of H2S was found in DR-6M and DR-LL than in DR-6W. Finally the level of oxidative stress was improved by DR-6M and DR-LL rather than by DR-6W. It concluded that aged rats had the ability to produce enough H2S on 30% DR interventions protecting against renal aging, and the effect of DR for long-term were more significant than that of DR for short-term.

SUBMITTER: Wang WJ 

PROVIDER: S-EPMC4960595 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats.

Wang Wen-Juan WJ   Cai Guang-Yan GY   Ning Yi-Chun YC   Cui Jing J   Hong Quan Q   Bai Xue-Yuan XY   Xu Xiao-Meng XM   Bu Ru R   Sun Xue-Feng XF   Chen Xiang-Mei XM  

Scientific reports 20160726


Renal aging is always accompanied by increased oxidative stress. Hydrogen sulfide (H2S) can be up-regulated by 50% dietary restriction (DR) for 7-day and can block mitochondrial oxidative stress. H2S production exerts a critical role in yeast, worm, and fruit fly models of DR-mediated longevity. In this study, we found that renal aging could be attenuated by 30% DR for 6-month (DR-6M) and life-long (DR-LL), but not for 6-week (DR-6W). The expressions of cystathionine-γ-lyase (CGL) and cystathion  ...[more]

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