Ontology highlight
ABSTRACT:
SUBMITTER: Erdel F
PROVIDER: S-EPMC4961120 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Erdel Fabian F Greene Eric C EC
Proceedings of the National Academy of Sciences of the United States of America 20160705 29
Histone modifications can redistribute along the genome in a sequence-independent manner, giving rise to chromatin position effects and epigenetic memory. The underlying mechanisms shape the endogenous chromatin landscape and determine its response to ectopically targeted histone modifiers. Here, we simulate linear and looping-driven spreading of histone modifications and compare both models to recent experiments on histone methylation in fission yeast. We find that a generalized nucleation-and- ...[more]