Structure of human Niemann-Pick C1 protein.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4961162 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Structure of human Niemann-Pick C1 protein.
Li Xiaochun X Wang Jiawei J Coutavas Elias E Shi Hang H Hao Qi Q Blobel Günter G
Proceedings of the National Academy of Sciences of the United States of America 20160615 29
Niemann-Pick C1 protein (NPC1) is a late-endosomal membrane protein involved in trafficking of LDL-derived cholesterol, Niemann-Pick disease type C, and Ebola virus infection. NPC1 contains 13 transmembrane segments (TMs), five of which are thought to represent a "sterol-sensing domain" (SSD). Although present also in other key regulatory proteins of cholesterol biosynthesis, uptake, and signaling, the structure and mechanism of action of the SSD are unknown. Here we report a crystal structure o ...[more]
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