Ontology highlight
ABSTRACT:
SUBMITTER: Pruneda JN
PROVIDER: S-EPMC4961225 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Pruneda Jonathan N JN Durkin Charlotte H CH Geurink Paul P PP Ovaa Huib H Santhanam Balaji B Holden David W DW Komander David D
Molecular cell 20160714 2
Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways, often in creative ways. CE clan proteases, specific hydrolases for ubiquitin-like modifications (SUMO and NEDD8) in eukaryotes, reportedly serve as bacterial effector proteins with deSUMOylase, deubiquitinase, or, even, acetyltransferase activities. Here, we characterize bacterial CE protease activities, revealing K63-linkage-specific deubiquitinases in human pathogens, such as Salmonella, Escherichia, ...[more]