Ontology highlight
ABSTRACT:
SUBMITTER: Ehle AR
PROVIDER: S-EPMC4961304 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Synlett : accounts and rapid communications in synthetic organic chemistry 20150914 19
We have developed an efficient method for the synthesis of (E)-trisubstituted vinyl bromides via a Friedel-Crafts-type addition of alkynes to oxocarbenium ions formed in situ from acetals. The success of this reaction relies on identification of MgBr<sub>2</sub>·OEt<sub>2</sub> as both a Lewis acid promoter and bromide source. This reaction employs simple, inexpensive starting materials and proceeds under mild conditions to allow the preparation of a range of vinyl bromide products in high yield ...[more]