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Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion.

ABSTRACT: The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.

SUBMITTER: Behrens AM 

PROVIDER: S-EPMC4961426 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion.

Behrens Adam M AM   Lee Nora G NG   Casey Brendan J BJ   Srinivasan Priya P   Sikorski Michael J MJ   Daristotle John L JL   Sandler Anthony D AD   Kofinas Peter P  

Advanced materials (Deerfield Beach, Fla.) 20151110 48

The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance. ...[more]

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