Ontology highlight
ABSTRACT:
SUBMITTER: Banushi B
PROVIDER: S-EPMC4961739 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature communications 20160720
Post-translational modifications are necessary for collagen precursor molecules (procollagens) to acquire final shape and function. However, the mechanism and contribution of collagen modifications that occur outside the endoplasmic reticulum and Golgi are not understood. We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for mod ...[more]