Ontology highlight
ABSTRACT:
SUBMITTER: van Lith SA
PROVIDER: S-EPMC4962051 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
van Lith Sanne A M SA Navis Anna C AC Lenting Krissie K Verrijp Kiek K Schepens Jan T G JT Hendriks Wiljan J A J WJ Schubert Nil A NA Venselaar Hanka H Wevers Ron A RA van Rooij Arno A Wesseling Pieter P Molenaar Remco J RJ van Noorden Cornelis J F CJ Pusch Stefan S Tops Bastiaan B Tops Bastiaan B Leenders William P J WP
Scientific reports 20160727
The majority of low-grade and secondary high-grade gliomas carry heterozygous hotspot mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or the mitochondrial variant IDH2. These mutations mostly involve Arg132 in IDH1, and Arg172 or Arg140 in IDH2. Whereas IDHs convert isocitrate to alpha-ketoglutarate (α-KG) with simultaneous reduction of NADP(+) to NADPH, these IDH mutants reduce α-KG to D-2-hydroxyglutarate (D-2-HG) while oxidizing NADPH. D-2-HG is a proposed oncometabolite, acting via ...[more]