Dataset Information

Who Is Vulnerable to Dengue Fever? A Community Survey of the 2014 Outbreak in Guangzhou, China.

ABSTRACT: Unprecedented dengue fever (DF) outbreaks impel China to develop useful disease control strategies. Integrated vector management (IVM) focuses on identifying vulnerable populations and interrupting human-vector contact; however, vulnerable populations have not been clearly identified in China. We conducted a case-control study during the initial stage of the 2014 DF outbreak in Guangzhou, China to assess risk factors for DF infection. Cases were randomly sampled from the National Notifiable Infectious Disease Reporting Information System (NNIDRIS). Controls were healthy individuals recruited from 17 DF infected communities through cluster sampling. A structured questionnaire on demographics, knowledge, practices, and living environment was administered to participants (165 cases; 492 controls). Logistic regression models identified characteristics of vulnerable populations. Awareness of dengue (OR = 0.08, 95% CI = 0.04-0.17), removing trash and stagnant water from around the residence (OR = 0.02, 95% CI = 0.00-0.17), and using mosquito repellent oils (OR = 0.36, 95% CI = 0.16-0.81) were protective factors. Living in an old flat or shed (OR = 2.38, 95% CI = 1.18-4.79) was a risk factor. Coils and bed nets were not protective due to incorrect knowledge of use. Using mosquito repellent oils and other protective measures can reduce vulnerability to DF infection.

SUBMITTER: Chen B

PROVIDER: S-EPMC4962253 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Who Is Vulnerable to Dengue Fever? A Community Survey of the 2014 Outbreak in Guangzhou, China.

Chen Bin B Yang Jun J Luo Lei L Yang Zhicong Z Liu Qiyong Q

International journal of environmental research and public health 20160714 7

Unprecedented dengue fever (DF) outbreaks impel China to develop useful disease control strategies. Integrated vector management (IVM) focuses on identifying vulnerable populations and interrupting human-vector contact; however, vulnerable populations have not been clearly identified in China. We conducted a case-control study during the initial stage of the 2014 DF outbreak in Guangzhou, China to assess risk factors for DF infection. Cases were randomly sampled from the National Notifiable Infe ...[more]

PMID: 27428986

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Project description:BackgroundDengue was regarded as a mild epidemic in mainland China transmitted by Aedes albopictus. However, the 2014 record-breaking outbreak in Guangzhou could change the situation. In order to provide an early warning of epidemic trends and provide evidence for prevention and control strategies, we seek to characterize the 2014 outbreak through application of detailed cases and entomological data, as well as phylogenetic analysis of viral envelope (E) gene.MethodsWe used case survey data identified through the Notifiable Infectious Disease Report System, entomological surveillance and population serosurvey, along with laboratory testing for IgM/IgG, NS1, and isolation of viral samples followed by E gene sequencing and phylogenetic analysis to examine the epidemiological and molecular characteristics of the outbreak.ResultsThe 2014 dengue outbreak in Guangzhou accounted for nearly 80% of total reported cases that year in mainland China; a total of 37,376 cases including 37,340 indigenous cases with incidence rate 2908.3 per million and 36 imported cases were reported in Guangzhou, with 14,055 hospitalized and 5 deaths. The epidemic lasted for 193 days from June 11 to December 21, with the highest incidence observed in domestic workers, the unemployed and retirees. The inapparent infection rate was 18.00% (135/750). In total, 96 dengue virus 1 (DENV-1) and 11 dengue virus 2 (DENV-2) strains were isolated. Phylogenetic analysis indicated that the DENV-1 strains were divided into genotype I and V, similar to the strains isolated in Guangzhou and Dongguan in 2013. The DENV-2 strains isolated were similar to those imported from Thailand on May 11 in 2014 and that imported from Indonesia in 2012.ConclusionsThe 2014 dengue epidemic was confirmed to be the first co-circulation of DENV-1 and DENV-2 in Guangzhou. The DENV-1 strain was endemic, while the DENV-2 strain was imported, being efficiently transmitted by the Aedes albopictus vector species at levels as high as Aedes aegypti.

Dataset Information

Who Is Vulnerable to Dengue Fever? A Community Survey of the 2014 Outbreak in Guangzhou, China.

Publications

Who Is Vulnerable to Dengue Fever? A Community Survey of the 2014 Outbreak in Guangzhou, China.

Similar Datasets

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