Ontology highlight
ABSTRACT:
SUBMITTER: Grone BP
PROVIDER: S-EPMC4962313 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Grone Brian P BP Maruska Karen P KP
Scientific reports 20160727
Gamma-aminobutyric acid (GABA) is a widely conserved signaling molecule that in animals has been adapted as a neurotransmitter. GABA is synthesized from the amino acid glutamate by the action of glutamate decarboxylases (GADs). Two vertebrate genes, GAD1 and GAD2, encode distinct GAD proteins: GAD67 and GAD65, respectively. We have identified a third vertebrate GAD gene, GAD3. This gene is conserved in fishes as well as tetrapods. We analyzed protein sequence, gene structure, synteny, and phylog ...[more]