Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG.

ABSTRACT:

Background

The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy.

Case presentation

We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and was refractory to high dose mitoxantrone/cytarabine and CLAG regimens.

Conclusion

This highly refractory pre-B Ph(-) ALL was induced to complete remission after one course of single agent blinatumomab.

SUBMITTER: Linder K 

PROVIDER: S-EPMC4962515 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature