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Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG.

ABSTRACT: BACKGROUND:The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy. CASE PRESENTATION:We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and was refractory to high dose mitoxantrone/cytarabine and CLAG regimens. CONCLUSION:This highly refractory pre-B Ph(-) ALL was induced to complete remission after one course of single agent blinatumomab.

SUBMITTER: Linder K

PROVIDER: S-EPMC4962515 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG.

Linder Katherine K Gandhiraj Deepthi D Hanmantgad Madhura M Seiter Karen K Liu Delong D

Experimental hematology & oncology 20150101

<h4>Background</h4>The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy.<h4>Case presentation</h4>We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and was refractory to high dose mitoxantrone/cytarabine and CLAG regimens.<h4>Conclusion</h4>This highly refractory pre-B Ph(-) ALL was induced to complete remission after ...[more]

PMID: 27468365

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