An exome array study of the plasma metabolome.
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ABSTRACT:
SUBMITTER: Rhee EP
PROVIDER: S-EPMC4962516 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
An exome array study of the plasma metabolome.
Rhee Eugene P EP Yang Qiong Q Yu Bing B Liu Xuan X Cheng Susan S Deik Amy A Pierce Kerry A KA Bullock Kevin K Ho Jennifer E JE Levy Daniel D Florez Jose C JC Kathiresan Sek S Larson Martin G MG Vasan Ramachandran S RS Clish Clary B CB Wang Thomas J TJ Boerwinkle Eric E O'Donnell Christopher J CJ Gerszten Robert E RE
Nature communications 20160725
The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study, with replication in 1,528 participants of the Atherosclerosis Risk in Communities Study. We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH an ...[more]
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