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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.


ABSTRACT: Mitochondria have a number of essential roles in neuronal function. Their complex mobility patterns within neurons are characterized by frequent changes in direction. Mobile mitochondria can become stationary or pause in regions that have a high metabolic demand and can move again rapidly in response to physiological changes. Defects in mitochondrial transport are implicated in the pathogenesis of several major neurological disorders. Research into the mechanisms that regulate mitochondrial transport is thus an important emerging frontier.

SUBMITTER: Sheng ZH 

PROVIDER: S-EPMC4962561 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.

Sheng Zu-Hang ZH   Cai Qian Q  

Nature reviews. Neuroscience 20120105 2


Mitochondria have a number of essential roles in neuronal function. Their complex mobility patterns within neurons are characterized by frequent changes in direction. Mobile mitochondria can become stationary or pause in regions that have a high metabolic demand and can move again rapidly in response to physiological changes. Defects in mitochondrial transport are implicated in the pathogenesis of several major neurological disorders. Research into the mechanisms that regulate mitochondrial tran  ...[more]

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