Dataset Information

Sieve-based coreference resolution enhances semi-supervised learning model for chemical-induced disease relation extraction.

ABSTRACT: The BioCreative V chemical-disease relation (CDR) track was proposed to accelerate the progress of text mining in facilitating integrative understanding of chemicals, diseases and their relations. In this article, we describe an extension of our system (namely UET-CAM) that participated in the BioCreative V CDR. The original UET-CAM system's performance was ranked fourth among 18 participating systems by the BioCreative CDR track committee. In the Disease Named Entity Recognition and Normalization (DNER) phase, our system employed joint inference (decoding) with a perceptron-based named entity recognizer (NER) and a back-off model with Semantic Supervised Indexing and Skip-gram for named entity normalization. In the chemical-induced disease (CID) relation extraction phase, we proposed a pipeline that includes a coreference resolution module and a Support Vector Machine relation extraction model. The former module utilized a multi-pass sieve to extend entity recall. In this article, the UET-CAM system was improved by adding a 'silver' CID corpus to train the prediction model. This silver standard corpus of more than 50 thousand sentences was automatically built based on the Comparative Toxicogenomics Database (CTD) database. We evaluated our method on the CDR test set. Results showed that our system could reach the state of the art performance with F1 of 82.44 for the DNER task and 58.90 for the CID task. Analysis demonstrated substantial benefits of both the multi-pass sieve coreference resolution method (F1?+?4.13%) and the silver CID corpus (F1?+7.3%).Database URL: SilverCID-The silver-standard corpus for CID relation extraction is freely online available at: https://zenodo.org/record/34530 (doi:10.5281/zenodo.34530).

SUBMITTER: Le HQ

PROVIDER: S-EPMC4962668 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Sieve-based coreference resolution enhances semi-supervised learning model for chemical-induced disease relation extraction.

Le Hoang-Quynh HQ Tran Mai-Vu MV Dang Thanh Hai TH Ha Quang-Thuy QT Collier Nigel N

Database : the journal of biological databases and curation 20160701

The BioCreative V chemical-disease relation (CDR) track was proposed to accelerate the progress of text mining in facilitating integrative understanding of chemicals, diseases and their relations. In this article, we describe an extension of our system (namely UET-CAM) that participated in the BioCreative V CDR. The original UET-CAM system's performance was ranked fourth among 18 participating systems by the BioCreative CDR track committee. In the Disease Named Entity Recognition and Normalizati ...[more]

PMID: 27630201

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Project description:Deep learning has achieved considerable success in medical image segmentation. However, applying deep learning in clinical environments often involves two problems: (1) scarcity of annotated data as data annotation is time-consuming and (2) varying attributes of different datasets due to domain shift. To address these problems, we propose an improved generative adversarial network (GAN) segmentation model, called U-shaped GAN, for limited-annotated chest radiograph datasets. The semi-supervised learning approach and unsupervised domain adaptation (UDA) approach are modeled into a unified framework for effective segmentation. We improve GAN by replacing the traditional discriminator with a U-shaped net, which predicts each pixel a label. The proposed U-shaped net is designed with high resolution radiographs (1,024 × 1,024) for effective segmentation while taking computational burden into account. The pointwise convolution is applied to U-shaped GAN for dimensionality reduction, which decreases the number of feature maps while retaining their salient features. Moreover, we design the U-shaped net with a pretrained ResNet-50 as an encoder to reduce the computational burden of training the encoder from scratch. A semi-supervised learning approach is proposed learning from limited annotated data while exploiting additional unannotated data with a pixel-level loss. U-shaped GAN is extended to UDA by taking the source and target domain data as the annotated data and the unannotated data in the semi-supervised learning approach, respectively. Compared to the previous models dealing with the aforementioned problems separately, U-shaped GAN is compatible with varying data distributions of multiple medical centers, with efficient training and optimizing performance. U-shaped GAN can be generalized to chest radiograph segmentation for clinical deployment. We evaluate U-shaped GAN with two chest radiograph datasets. U-shaped GAN is shown to significantly outperform the state-of-the-art models.

Dataset Information

Sieve-based coreference resolution enhances semi-supervised learning model for chemical-induced disease relation extraction.

Publications

Sieve-based coreference resolution enhances semi-supervised learning model for chemical-induced disease relation extraction.

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