Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

ABSTRACT:

Purpose

Acute pancreatitis is one of the common causes of asparaginase intolerance. The mechanism is unknown, and genetic predisposition to asparaginase-induced pancreatitis has not been previously identified.

Methods

To determine clinical risk factors for asparaginase-induced pancreatitis, we studied a cohort of 5,185 children and young adults with acute lymphoblastic leukemia, including 117 (2.3%) who were diagnosed with at least one episode of acute pancreatitis during therapy. A genome-wide association study was performed in the cohort and in an independent case-control group of 213 patients to identify genetic risk factors.

Results

Risk factors associated with pancreatitis included genetically defined Native American ancestry (P < .001), older age (P < .001), and

SUBMITTER: Liu C 

PROVIDER: S-EPMC4962704 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature