ATR-mediated regulation of nuclear and cellular plasticity.
Ontology highlight
ABSTRACT:
SUBMITTER: Kidiyoor GR
PROVIDER: S-EPMC4962764 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
ATR-mediated regulation of nuclear and cellular plasticity.
Kidiyoor Gururaj Rao GR Kumar Amit A Foiani Marco M
DNA repair 20160516
ATR (Ataxia Telangiectasia and Rad3-related) is a member of the Phosphatidylinositol 3-kinase-related kinases (PIKKs) family, amongst six other vertebrate proteins known so far. ATR is indispensable for cell survival and its essential role is in sensing DNA damage and initiating appropriate repair responses. In this review we highlight emerging and recent observations connecting ATR to alternative roles in controlling the nuclear envelope, nucleolus, centrosome and other organelles in response t ...[more]
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