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Impact of host genetic polymorphisms on vaccine induced antibody response.


ABSTRACT: Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response.

SUBMITTER: Linnik JE 

PROVIDER: S-EPMC4962936 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Impact of host genetic polymorphisms on vaccine induced antibody response.

Linnik Janina E JE   Egli Adrian A  

Human vaccines & immunotherapeutics 20160125 4


Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response. ...[more]

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