Ontology highlight
ABSTRACT:
SUBMITTER: Maisel D
PROVIDER: S-EPMC4963023 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Maisel Daniela D Birzele Fabian F Voss Edgar E Nopora Adam A Bader Sabine S Friess Thomas T Goller Bernhard B Laifenfeld Daphna D Weigand Stefan S Runza Valeria V
PloS one 20160727 7
CD44, a transmembrane receptor reported to be involved in various cellular functions, is overexpressed in several cancer types and supposed to be involved in the initiation, progression and prognosis of these cancers. Since the sequence of events following the blockage of the CD44-HA interaction has not yet been studied in detail, we profiled xenograft tumors by RNA Sequencing to elucidate the mode of action of the anti-CD44 antibody RG7356. Analysis of tumor and host gene-expression profiles le ...[more]