Unknown

Dataset Information

0

Simultaneous bilateral laser therapy accelerates recovery after noise-induced hearing loss in a rat model.


ABSTRACT: Noise-induced hearing loss is a common type of hearing loss. The effects of laser therapy have been investigated from various perspectives, including in wound healing, inflammation reduction, and nerve regeneration, as well as in hearing research. A promising feature of the laser is its capability to penetrate soft tissue; depending on the wavelength, laser energy can penetrate into the deepest part of the body without damaging non-target soft tissues. Based on this idea, we developed bilateral transtympanic laser therapy, which uses simultaneous laser irradiation in both ears, and evaluated the effects of bilateral laser therapy on cochlear damage caused by noise overexposure. Thus, the purpose of this research was to assess the benefits of simultaneous bilateral laser therapy compared with unilateral laser therapy and a control. Eighteen Sprague-Dawley rats were exposed to narrow-band noise at 115 dB SPL for 6 h. Multiple auditory brainstem responses were measured after each laser irradiation, and cochlear hair cells were counted after the 15th such irradiation. The penetration depth of the 808 nm laser was also measured after sacrifice. Approximately 5% of the laser energy reached the contralateral cochlea. Both bilateral and unilateral laser therapy decreased the hearing threshold after noise overstimulation in the rat model. The bilateral laser therapy group showed faster functional recovery at all tested frequencies compared with the unilateral laser therapy group. However, there was no difference in the endpoint ABR results or final hair cell survival, which was analyzed histologically.

SUBMITTER: Lee JH 

PROVIDER: S-EPMC4963219 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications

Simultaneous bilateral laser therapy accelerates recovery after noise-induced hearing loss in a rat model.

Lee Jae-Hun JH   Chang So-Young SY   Moy Wesley J WJ   Oh Connie C   Kim Se-Hyung SH   Rhee Chung-Ku CK   Ahn Jin-Chul JC   Chung Phil-Sang PS   Jung Jae Yun JY   Lee Min Young MY  

PeerJ 20160721


Noise-induced hearing loss is a common type of hearing loss. The effects of laser therapy have been investigated from various perspectives, including in wound healing, inflammation reduction, and nerve regeneration, as well as in hearing research. A promising feature of the laser is its capability to penetrate soft tissue; depending on the wavelength, laser energy can penetrate into the deepest part of the body without damaging non-target soft tissues. Based on this idea, we developed bilateral  ...[more]

Similar Datasets

| S-EPMC10767431 | biostudies-literature
2024-06-24 | GSE252285 | GEO
2024-07-08 | GSE271449 | GEO
| S-EPMC3129354 | biostudies-literature
| S-EPMC6728038 | biostudies-literature
| S-EPMC10967582 | biostudies-literature
| S-EPMC8180578 | biostudies-literature
| S-EPMC5527323 | biostudies-literature
| S-EPMC3102156 | biostudies-other
| S-EPMC5864918 | biostudies-literature