Ontology highlight
ABSTRACT:
SUBMITTER: Weinsheimer S
PROVIDER: S-EPMC4963303 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Weinsheimer Shantel S Bendjilali Nasrine N Nelson Jeffrey J Guo Diana E DE Zaroff Jonathan G JG Sidney Stephen S McCulloch Charles E CE Al-Shahi Salman Rustam R Berg Jonathan N JN Koeleman Bobby P C BP Simon Matthias M Bostroem Azize A Fontanella Marco M Sturiale Carmelo L CL Pola Roberto R Puca Alfredo A Lawton Michael T MT Young William L WL Pawlikowska Ludmila L Klijn Catharina J M CJ Kim Helen H
Journal of neurology, neurosurgery, and psychiatry 20160127 9
<h4>Background</h4>The pathogenesis of sporadic brain arteriovenous malformations (BAVMs) remains unknown, but studies suggest a genetic component. We estimated the heritability of sporadic BAVM and performed a genome-wide association study (GWAS) to investigate association of common single nucleotide polymorphisms (SNPs) with risk of sporadic BAVM in the international, multicentre Genetics of Arteriovenous Malformation (GEN-AVM) consortium.<h4>Methods</h4>The Caucasian discovery cohort included ...[more]