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An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment.


ABSTRACT: Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.

SUBMITTER: Xia S 

PROVIDER: S-EPMC4963991 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment.

Xia Shijin S   Zhang Xinyan X   Zheng Songbai S   Khanabdali Ramin R   Kalionis Bill B   Wu Junzhen J   Wan Wenbin W   Tai Xiantao X  

Journal of immunology research 20160714


Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by  ...[more]

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