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Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides.

ABSTRACT: Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs.

SUBMITTER: Li H

PROVIDER: S-EPMC4964399 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides.

Li Hao H Anuwongcharoen Nuttapat N Malik Aijaz Ahmad AA Prachayasittikul Virapong V Wikberg Jarl E S JE Nantasenamat Chanin C

International journal of molecular sciences 20160630 7

Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Althou ...[more]

PMID: 27376281

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