Ontology highlight
ABSTRACT:
SUBMITTER: Tokito A
PROVIDER: S-EPMC4964549 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Tokito Akinori A Jougasaki Michihisa M
International journal of molecular sciences 20160721 7
The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and they and their substrates are widely expressed in many tissues. Recent growing evidence has established that MMP not only can degrade a variety of components of extracellular matrix, but also can cleave and activate various non-matrix proteins, including cytokines, chemokines and growth factors, contributing to both physi ...[more]