Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons.

ABSTRACT:

Background

Influenza-related complications are highest in the elderly. Vaccine efficacy is lower due to immunosenescence. Vitamin D's immunomodulatory role was studied in the context of vaccine response.

Methods

We evaluated the effect of baseline 25-(OH) D on vaccine-induced immunological response in a cohort of 159 healthy subjects ages 50-74 in Rochester, MN, who received one dose of seasonal trivalent 2010-2011 influenza vaccine, containing A/California/H1N1- like virus. We examined correlations between 25-(OH) D, leptin, and leptin-related gene SNPs to understand the role of leptin and vitamin D's effects.

Results

The median (IQR) baseline for total 25-(OH) D was 44.4 ng/mL (36.6-52.2 ng/mL). No correlation was observed with age. No correlation between 25-(OH) D

SUBMITTER: Sadarangani SP 

PROVIDER: S-EPMC4964629 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature