Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.
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ABSTRACT:
SUBMITTER: Silvino AC
PROVIDER: S-EPMC4965052 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.
Silvino Ana Carolina Rios AC Costa Gabriel Luiz GL Araújo Flávia Carolina Faustino de FC Ascher David Benjamin DB Pires Douglas Eduardo Valente DE Fontes Cor Jesus Fernandes CJ Carvalho Luzia Helena LH Brito Cristiana Ferreira Alves de CF Sousa Tais Nobrega TN
PloS one 20160728 7
Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it has been proposed that a proportion of these cases are due to primaquine (PQ) treatment failure caused by polymorphisms in cytochrome P-450 2D6 (CYP2D6). Here, we present evidence that CYP2D6 polymorphisms are implicated in PQ failure, which was reinforced by findings in genetically similar parasites, and may explain a number of vivax relapses. Using a computational approach, these polymorphisms were pre ...[more]
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