Ontology highlight
ABSTRACT:
SUBMITTER: Walton SJ
PROVIDER: S-EPMC4965260 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Walton Sarah-Jane SJ Lewis Amy A Jeffery Rosemary R Thompson Hannah H Feakins Roger R Giannoulatou Eleni E Yau Christopher C Lindsay James O JO Clark Susan K SK Silver Andrew A
Oncoscience 20160630 5-6
Familial adenomatous polyposis (FAP) is rare affecting 1 in 10,000 people and a subset (10%) are at risk of myofibroblastic desmoid tumours (DTs) after colectomy to prevent cancer. DTs are a major cause of morbidity and mortality. The absence of markers to monitor progression and a lack of treatment options are significant limitations to clinical management. We investigated microRNAs (miRNA) levels in DTs and serum using expression array analysis on two independent cohorts of FAP patients (total ...[more]