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Vaccinations for Neuroinfectious Disease: A Global Health Priority.

ABSTRACT: Vaccines for neuroinfectious diseases are becoming an ever-increasing global health priority, as neurologic manifestations and sequelae from existing and emerging central nervous system infections account for significant worldwide morbidity and mortality. The prevention of neurotropic infections can be achieved through globally coordinated vaccination campaigns, which have successfully eradicated nonzoonotic agents such as the variola viruses and, hopefully soon, poliovirus. This review discusses vaccines that are currently available or under development for zoonotic flaviviruses and alphaviruses, including Japanese and tick-borne encephalitis, yellow fever, West Nile, dengue, Zika, encephalitic equine viruses, and chikungunya. Also discussed are nonzoonotic agents, including measles and human herpesviruses, as well as select bacterial, fungal, and protozoal pathogens. While therapeutic vaccines will be required to treat a multitude of ongoing infections of the nervous system, the ideal vaccination strategy is pre-exposure vaccination, with the ultimate goals of minimizing disease associated with zoonotic viruses and the total eradication of nonzoonotic agents.

SUBMITTER: Leibovitch EC

PROVIDER: S-EPMC4965415 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Vaccinations for Neuroinfectious Disease: A Global Health Priority.

Leibovitch Emily C EC Jacobson Steven S

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20160701 3

Vaccines for neuroinfectious diseases are becoming an ever-increasing global health priority, as neurologic manifestations and sequelae from existing and emerging central nervous system infections account for significant worldwide morbidity and mortality. The prevention of neurotropic infections can be achieved through globally coordinated vaccination campaigns, which have successfully eradicated nonzoonotic agents such as the variola viruses and, hopefully soon, poliovirus. This review discusse ...[more]

PMID: 27365085

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Dataset Information

Vaccinations for Neuroinfectious Disease: A Global Health Priority.

Publications

Vaccinations for Neuroinfectious Disease: A Global Health Priority.

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