GenomeRunner web server: regulatory similarity and differences define the functional impact of SNP sets.

ABSTRACT:

Motivation

The growing amount of regulatory data from the ENCODE, Roadmap Epigenomics and other consortia provides a wealth of opportunities to investigate the functional impact of single nucleotide polymorphisms (SNPs). Yet, given the large number of regulatory datasets, researchers are posed with a challenge of how to efficiently utilize them to interpret the functional impact of SNP sets.

Results

We developed the GenomeRunner web server to automate systematic statistical analysis of SNP sets within a regulatory context. Besides defining the functional impact of SNP sets, GenomeRunner implements novel regulatory similarity/differential analyses, and cell type-specific regulatory enrichment analysis. Validated against literature- and disease ontology-based approaches, analy

SUBMITTER: Dozmorov MG 

PROVIDER: S-EPMC4965636 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature