Ontology highlight
ABSTRACT:
SUBMITTER: Rusli F
PROVIDER: S-EPMC4965761 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Rusli Fenni F Deelen Joris J Andriyani Evi E Boekschoten Mark V MV Lute Carolien C van den Akker Erik B EB Müller Michael M Beekman Marian M Steegenga Wilma T WT
Scientific reports 20160729
Fibroblast growth factor 21 (Fgf21) has emerged as a potential plasma marker to diagnose non-alcoholic fatty liver disease (NAFLD). To study the molecular processes underlying the association of plasma Fgf21 with NAFLD, we explored the liver transcriptome data of a mild NAFLD model of aging C57BL/6J mice at 12, 24, and 28 months of age. The plasma Fgf21 level significantly correlated with intrahepatic triglyceride content. At the molecular level, elevated plasma Fgf21 levels were associated with ...[more]