Ontology highlight
ABSTRACT:
SUBMITTER: Gordts PL
PROVIDER: S-EPMC4966320 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Gordts Philip L S M PL Nock Ryan R Son Ni-Huiping NH Ramms Bastian B Lew Irene I Gonzales Jon C JC Thacker Bryan E BE Basu Debapriya D Lee Richard G RG Mullick Adam E AE Graham Mark J MJ Goldberg Ira J IJ Crooke Rosanne M RM Witztum Joseph L JL Esko Jeffrey D JD
The Journal of clinical investigation 20160711 8
Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels. Antisense oligonucleotides (ASOs) for ApoC-III reduce plasma TGs in primates and mice, but the underlying mechanism of action remains controversial. We determined that a murine-specific ApoC-III-targeting ASO reduces fasting TG levels through a mechanism that is dependent on low-density lipoprotein receptors (LDLRs) a ...[more]